Abstract: Advancing technology has facilitated widespread application of electronic devices to monitor fish behavior, often resulting in cumbersome data sets and difficulty interpreting results. Consequently, successful telemetry evaluations are often a result of (1) a well-planned study design, (2) accurate and efficient data management, and (3) appropriate statistical approaches to inform the research question. We describe several case studies with different technologies, species, and objectives to highlight the importance of data management and analysis. These examples include passage and behavior evaluations of salmon at various life stages, lamprey behavior, and sturgeon supplementation using active and passive telemetry, multiple data streams, and diverse statistical approaches. The successes and shortcomings in the Pacific Northwest can inform telemetry evaluations in both connected and impounded river systems around the globe.