Sex work has always been relevant to queer and trans communities, both as a livelihood option and as an issue that critically informs the space between social and political margins, and the centralities of queer and trans communities. The vital set of issues raised by the intersections of sex worker and queer populations has not always been addressed by LGBT/Q organizations, however. This essay brings the complex history of those intersections into sharp relief, in order to make a case for the importance of thinking politically about sex work and queer life today.