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Fat Lowering Effects of Piperine in Caenorhabditis elegans

Abstract
P iperine is an alkaloid found in pepper plant, w hich exhibits many health benefits including anti aging, anti cancer, anti diabetic, and anti inflammatory effects. However, the anti obesity research of piperine is limited. Therefore, th is study was done to determine the effects of piperine on fat accumulation, using in vivo model, Caenor habditis elegans . Treatment with 100 μ M piperine reduce fat content of wild type C. elegans by 17% over control. Pumping rate was not affected by piperine, suggesting piperine has no effects on food intake of worms. Mutant strains were tested to determine t he fat reducing mechanisms. daf 2 , daf 12 , and daf 12 mutant strains failed to decrease the fat content by piperine, suggesting piperine may regulates fat accumulation via DAF 2, DAF 12, and DAF 16.
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