This dissertation proposes a series of multi-sensor localization and tracking algorithms particularly developed for two important application domains, which are disaster management and indoor wayfinding for blind and visually impaired (BVI) users. For disaster management, we developed two different localization algorithms, one each for Radio Frequency Identification (RFID) and Bluetooth Low Energy (BLE) technology, which enable the disaster management system to track patients in real-time. Both algorithms work in the absence of any pre-deployed infrastructure along with smartphones and wearable devices. Regarding indoor wayfinding for BVI users, we have explored several types of indoor positioning techniques including BLE-based, inertial, visual and hybrid approaches to offer accurate and reliable location and orientation in complex navigation spaces. In this dissertation, significant contributions have been made in the design and implementation of various localization and tracking algorithms under different requirements of certain applications.