Background: Human immunodeficiency virus (HIV), chlamydia, and gonorrhea prevalence in young adults is higher than in any other segment of the population and has been increasing at alarming rates. Young adults on university campuses experience high rates of sexually transmitted infections (STI), yet many are not getting tested due to a lack of easy-to-access screening opportunities. Young men who have sex with men and minorities are at increased risk. Methods: This DNP Project was a program evaluation of the nurse-led STI screening clinics held at a northeastern university in the fall of 2016. The evaluation included patient and provider surveys, which collected demographic information, risk factors, as well as satisfaction feedback. The health service laboratory provided data on positivity rates and numbers of tests conducted before and during the study period. The goal was to assess the effectiveness of off-site clinics in increasing testing rates, decreasing positivity rates, and in reaching high-risk students. Results: Surveys indicated that students at high-risk for STIs or HIV attended the clinics in high numbers. Patient satisfaction was high at 95% overall, although there were confidentiality concerns related to billing insurance. The HIV and STI testing rate increased by 25% and 33% respectively between 2015 and 2016. Chlamydia and gonorrhea positive test rates increased between 2015 and 2016. Posters and the website were the most noted method of communication. Staff satisfaction was high, 67% of staff indicated a need for increased staffing. Discussion: Nurse-led STI clinics were able to increase STI and HIV screening opportunities particularly for those at increased risk for STI or HIV acquisition. Positivity rates are increasing nationwide and increased awareness, screening and treatment is needed.