Abstract Background: Access to support for behavioral and mental health in adolescents and young adults difficult. Depressive symptoms go unrecognized which can lead to severe symptoms, hospitalizations, and suicides. The lack of mental health services challenge the management of depression in this age group. Mindfulness may be a helpful tool in supporting mental health. Purpose: The purpose of this project was to improve depression symptoms among youth through engagement in mindfulness activities. Methods: A pre/post-intervention approach was used to measure the effectiveness of a synchronous, online educational platform to guide participants in mindfulness activities. Practice sessions were utilized based on evidence of previous studies and designed to support reduction of depressive symptoms. A paired t-test examined changes in PHQ-9 survey scores before and after mindfulness education and practice sessions. Results: The paired t-test results demonstrated that there was a significant difference between the two groups of PHQ-9 scores (p<0.05). Reduction of PHQ-9 scores indicated the depression symptoms were significantly improved after mindfulness education in adolescents and young adults. Discussion: Guiding participants through various forms of mindfulness activities allows them to understand and implement self-care. Participants chose the most effective mindfulness tool to support their own mental health. Strengths and weaknesses which gave rise to suggestions for further projects while nursing implications supported the quality improvement goal for the clinical site. Conclusion: While mental health concerns continue to rise, nursing can support adolescents and young adults to develop self-care strategies like mindfulness practice in order to minimize depression symptoms, build resilience, and promote wellness.