Wearable electronics are a valuable tool to increase consumer access to real-time and long-term health care monitoring. The development of these technologies can also lead to major advancements in the field, such as self-charging systems that are completely removed from the electrical grid. However, much of the wearable technology available commercially contain rigid components, use unsustainable synthetic methods, or undesirable materials. The field has thus been moving towards wearables that mimic textiles or use textiles as a substrate. Herein, we discuss the use of oxidative chemical vapor deposition (oCVD) to produce textiles coated with poly(3,4-ethylenedioxythiophene) known as PEDOT-Cl. We evaluate the thermoelectric, thermoresistive, and hygroresistive properties of these PEDOT-Cl fabrics. We also explore the applications of these properties by creating humidity sensors, temperature sensors, and thermoelectric generators integrated with clothing. In general, we discuss the process of designing a wearable to best accommodate the desired application.