Off-campus UMass Amherst users: To download campus access dissertations, please use the following link to log into our proxy server with your UMass Amherst user name and password.

Non-UMass Amherst users: Please talk to your librarian about requesting this dissertation through interlibrary loan.

Dissertations that have an embargo placed on them will not be available to anyone until the embargo expires.


Access Type

Open Access Thesis

Document Type


Degree Program

Food Science

Degree Type

Master of Science (M.S.)

Year Degree Awarded


Month Degree Awarded



P iperine is an alkaloid found in pepper plant, w hich exhibits many health benefits including anti aging, anti cancer, anti diabetic, and anti inflammatory effects. However, the anti obesity research of piperine is limited. Therefore, th is study was done to determine the effects of piperine on fat accumulation, using in vivo model, Caenor habditis elegans . Treatment with 100 μ M piperine reduce fat content of wild type C. elegans by 17% over control. Pumping rate was not affected by piperine, suggesting piperine has no effects on food intake of worms. Mutant strains were tested to determine t he fat reducing mechanisms. daf 2 , daf 12 , and daf 12 mutant strains failed to decrease the fat content by piperine, suggesting piperine may regulates fat accumulation via DAF 2, DAF 12, and DAF 16.


First Advisor

Yeonhwa Park