Document Type

Campus-Only Access for Five (5) Years

Embargo Period

3-1-2019

Degree Program

Neuroscience & Behavior

Degree Type

Master of Science (M.S.)

Year Degree Awarded

2018

Month Degree Awarded

September

Abstract

The accessory olfactory bulb (AOB) processes pheromonal signals which in turn drive social behaviors. Here we identify a tract of aromatase-expressing (arom+) fibers in the dorsal lateral olfactory tract (dLOT) which terminate in the granule cell layer (GCL) of the AOB. We utilized a retrograde tracer in aromatase reporter animals to delineate the source of these fibers. We show that these input fibers emerge almost exclusively from a contiguous population of arom+ neurons that spans the bed nucleus of the accessory olfactory tract (BAOT) and posterioventral subnucleus of the medial amygdala (MeApv). This population of neurons expresses the estrogen receptor alpha and contains more aromatase neurons in male mice than female mice. Thus, this population of feedback neurons can detect neuroendocrine changes and modulate the output of AOB projection neurons in a way that is sexually dimorphic and could influence every downstream target of the AOB.

First Advisor

Joseph Bergan

Second Advisor

Mariana Pereira

Third Advisor

Luke Remage-Healey

Available for download on Friday, March 01, 2019

Share

COinS