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ORCID
N/A
Access Type
Open Access Thesis
Document Type
thesis
Degree Program
Food Science
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2019
Month Degree Awarded
February
Abstract
Deltamethrin is a widely used type-II pyrethroid insecticide in agricultural, industrial and domestic pest control. Previous studies have shown that deltamethrin can induce ER stress response in vivo. However, it is still unclear whether deltamethrin can disturb protein homeostasis. To investigate how deltamethrin affects ER protein homeostasis, we used a C. elegans model of protein misfolding. In the current study, deltamethrin induced ER stress response in C. elegans. Moreover, exposure to deltamethrin increased the accumulation of unfolded and misfolded proteins in a C. elegans model of polyglutamine aggregation in body wall muscles. Deltamethrin also increased the toxicity of polyglutamine aggregates in C. elegans, as characterized by decreased locomotion with deltamethrin treatment. These data indicate that exposure to deltamethrin can induce ER stress response, increase the accumulation and proteotoxicity of unfolded and misfolded proteins. As ER stress plays a pathological role in many diseases, these findings provide evidence for the potential pathological role of deltamethrin in ER stress-related diseases.
DOI
https://doi.org/10.7275/13470528
First Advisor
Yeonhwa Park
Recommended Citation
Xu, Yuejia, "Deltamethrin Induces Endoplasmic Reticulum Stress and Increases Proteotoxicity in Caenorhabditis Elegans" (2019). Masters Theses. 753.
https://doi.org/10.7275/13470528
https://scholarworks.umass.edu/masters_theses_2/753