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Open Access Thesis
Neuroscience & Behavior
Master of Science (M.S.)
Year Degree Awarded
Month Degree Awarded
The medial amygdala (MeA) is a central node in the interwoven circuits that regulate social behavior based on pheromones. Aromatase-expressing (arom+) neurons in the MeA are key for the establishment and maintenance of sex differences. Here, we characterized the intrinsic electrophysiological properties of arom+ neurons and non-aromatase (arom-) neurons in the MeA of male and female mice. Most electrophysiological properties were similar for arom+ neurons in the MeA between sexes, but the relative refractory period was twice as large in female mice. We also show that the firing pattern and firing frequency is markedly different between arom+ and arom- neurons. The activity of MeA neurons could be modulated by estradiol, which reduced activity in arom+ neurons in males. The differences between arom+ and arom- neurons were observed in both sexes suggesting that aromatase expression delineates a neural population in the MeA with similar and unique electrophysiological properties.
Correia, Marcelo Henrique, "SEX SPECIFIC ELECTROPHYSIOLOGY OF AROMATASE NEURONS IN THE MEDIAL AMYGDALA" (2019). Masters Theses. 824.