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ORCID
https://orcid.org/0000-0003-0568-0685
Access Type
Open Access Thesis
Document Type
thesis
Degree Program
Food Science
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2020
Month Degree Awarded
September
Abstract
Berberine is an isoquinoline alkaloid found in some plants and has many bioactivities including anti-microbial, lipid- and glucose-lowering, anti-cancer, anti-inflammatory, etc. However, there is limited knowledge about berberine’s effects on development and locomotive activity. Herein, in vivo studies were conducted to determine these effects of berberine using Caenorhabditis elegans as an in vivo model. Treatment of berberine at 50 μM starting at L1 stage significantly retarded the growth rate of nematodes, and reduced the length, width and moving speed of worms by 19%, 12% and 29%, respectively, compared to the control. In addition, triglycerides (TG) and protein content in worms was reduced by 23% and 28%, respectively, after berberine treatment from L1 stage compared with the control group. However, no significance was observed when berberine was treated from young adult stage. These findings suggest that berberine has effects on development in C. elegans.
DOI
https://doi.org/10.7275/18684482
First Advisor
Yeonhwa Park
Recommended Citation
Qian, Zhuojia, "Effects of Berberine on Development in Caenorhabditis elegans" (2020). Masters Theses. 987.
https://doi.org/10.7275/18684482
https://scholarworks.umass.edu/masters_theses_2/987