Publication Date
2015
Journal or Book Title
Technometrics
Abstract
When conducting high-throughput biological experiments, it is often necessary to develop a protocol that is both inexpensive and robust. Standard approaches are either not cost-effective or arrive at an optimized protocol that is sensitive to experimental variations. Here, we describe a novel approach that directly minimizes the cost of the protocol while ensuring the protocol is robust to experimental variation. Our approach uses a risk-averse conditional value-at-risk criterion in a robust parameter design framework. We demonstrate this approach on a polymerase chain reaction protocol and show that our improved protocol is less expensive than the standard protocol and more robust than a protocol optimized without consideration of experimental variation.
DOI
https://doi.org/10.1080/00401706.2014.915890
Pages
234-244
Volume
57
Issue
2
Recommended Citation
Flaherty, Patrick and Davis, Ronald W., "Robust Optimization of Biological Protocols" (2015). Technometrics. 1208.
https://doi.org/10.1080/00401706.2014.915890
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