Publication Date
2020
Journal or Book Title
Viruses
Abstract
Kaposi’s sarcoma-associated herpesvirus (KSHV) induces life-long infections and has evolved many ways to exert extensive control over its host’s transcriptional and post-transcriptional machinery to gain better access to resources and dampened immune sensing. The hallmark of this takeover is how KSHV reshapes RNA fate both to control expression of its own gene but also that of its host. From the nucleus to the cytoplasm, control of RNA expression, localization, and decay is a process that is carefully tuned by a multitude of factors and that can adapt or react to rapid changes in the environment. Intriguingly, it appears that KSHV has found ways to co-opt each of these pathways for its own benefit. Here we provide a comprehensive review of recent work in this area and in particular recent advances on the post-transcriptional modifications front. Overall, this review highlights the myriad of ways KSHV uses to control RNA fate and gathers novel insights gained from the past decade of research at the interface of RNA biology and the field of KSHV research.
DOI
https://doi.org/10.3390/v12091024
Volume
12
Special Issue
New Advances in Kaposi's Sarcoma-Associated Herpesvirus Research
Issue
9
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Macveigh-Fierro, Daniel; Rodriguez, William; Miles, Jacob; and Muller, Mandy, "Stealing the Show: KSHV Hijacks Host RNA Regulatory Pathways to Promote Infection" (2020). Viruses. 334.
https://doi.org/10.3390/v12091024