Doctor of Nursing Practice (DNP) Projects
Access Control
Open Access
Degree Program
Doctor of Nursing Practice
Degree Track
Post Master's DNP Completion
Year Degree Awarded
2021
DOI
https://doi.org/10.7275/22557398
Month Degree Awarded
May
Keywords
Pharmacogenomics, psychiatry, major depression, nursing, innovation adoption
Advisor
Pamela Aselton PhD, MPH, FNP-BC
DNP Project Chair
Pamela Aselton PhD, MPH, FNP-BC
DNP Project Member Name
Jeungok Choi, RN, PhD MPH
DNP Project Outside Member Name
Louis A. Velazquez, MD, DFAPA
Abstract
Abstract
Background: Treatment of major depression follows the guidelines from evidence-based medicine established algorithms; however, 50% of patients diagnosed with major depressive disorder do not respond to their first medication trial, and 70% may go through four treatment attempts before achieving remission.
Purpose: To demonstrate the value of pharmacogenomic testing as a treatment-guidance technology in patients with resistant depression and assess healthcare providers' motivation to adopt the technology.
Methods: A retrospective chart review of (N = 73) patients' treatment response measured by the pre-post PHQ-9 depression scale after pharmacogenomic guided medication intervention with descriptive statistics and paired t-test. The project also assessed providers' motivation to adopt and use pharmacogenomic testing by completing the providers' motivation scale (PMA) before and after viewing an educational session on the subject.
Results: A significant improvement in mood with a mean decrease of 10 points in the post PHQ-9 scores ( p = .000 < .001) in 53% of the subjects, and 33% had scores that ranked within remission. Most patients (60%) responded to 1.3 medications post pharmacogenomic treatment. The providers were motivated to learn new technology and gain knowledge derived from current information for patient care.
Conclusions: These are significant findings corresponding to the new evidence research in pharmacogenomics supporting the use of the technology as a therapeutic resource for treatment-resistant depression patients.
Keywords: pharmacogenomics, psychiatry, major depression, nursing,
innovation adoption
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