Publication Date
2020
Journal or Book Title
Bioengineering
Abstract
There are currently multiple approaches to facilitate gene therapy via intramuscular gene delivery, such as electroporation, viral delivery, or direct DNA injection with or without polymeric carriers. Each of these methods has benefits, but each method also has shortcomings preventing it from being established as the ideal technique. A promising method, ultrasound-mediated gene delivery (or sonodelivery) is inexpensive, widely available, reusable, minimally invasive, and safe. Hurdles to utilizing sonodelivery include choosing from a large variety of conditions, which are often dependent on the equipment and/or research group, and moderate transfection efficiencies when compared to some other gene delivery methods. In this review, we provide a comprehensive look at the breadth of sonodelivery techniques for intramuscular gene delivery and suggest future directions for this continuously evolving field.
DOI
https://doi.org/10.3390/bioengineering7030107
Special Issue
Advances in Skeletal Muscle Tissue Engineering
Volume
7
Issue
3
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Decker, Richard E.; Lamantia, Zachary E.; Emrick, Todd S.; and Figueiredo, Marxa L., "Sonodelivery in Skeletal Muscle: Current Approaches and Future Potential" (2020). Bioengineering. 1160.
https://doi.org/10.3390/bioengineering7030107