Salthouse, Christopher D.Jackson, Robert W.Ganesan, Deepak K.Wang, Hongtao2024-04-262024-04-262016-052016-0510.7275/8391959.0https://hdl.handle.net/20.500.14394/19909Modern laboratory equipments to measure the excited-state lifetime of fluorophores usually include an expensive picosecond pulsed-laser excitation source, a fragile photomultiplier tube, and a large instrument body for optics. A portable and robust device to make fluorescence lifetime measurement in nanosecond scale is of great attraction for chemists and biologists. This dissertation reports the development of a portable LED time-domain fluorimeter from an all-solid-state discrete-component prototype to its advanced CMOS integrated circuit implementation. The motivation of the research is to develop a multiplexed fluorimeter for point-of-care diagnosis. Instruments developed by this novel method have higher fill factor, are more portable, and are fabricated at lower cost.Fluorescence lifetimeTime-domain FluorimeterCMOS Active Pixel SensorCMOS imagerBioimaging and Biomedical OpticsBiomedicalBiomedical Devices and InstrumentationElectrical and ElectronicsVLSI and Circuits, Embedded and Hardware SystemsDissertation (Open Access)