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Hypothalamus, Rats, Obesity, Ovaries


Following bilateral lesions of the lateral hypothalamus animals are rendered completely aphagic and adipsic (Anand and Brobeck, 1951; Teitelbaum and Stellar, 1954). If not maintained by intragastric feeding, rats will eventually die of starvation and dehydration. However, if the animals are kept alive a gradual recovery of food and water intake will occur. This recovery period has been extensively and carefully studied, and four distinct recovery stages have been identified (Teitelbaum, 1961; Teitelbaum and Epstein, 1962). The first stage of recovery is characterized by the animal's refusal of all food and water. In the second stage wet and palatable foods are accepted, although not in sufficient quantities to maintain life. During the third phase, the animal is able to regulate its caloric intake on wet and palatable foods, but is unable to regulate its weight on dry food. Finally, in the fourth stage the lateral hypothalamic lesioned animal will accept dry food and water in sufficient amounts to maintain life.