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Title
The discriminative stimulus properties of fenfluramine: evidence for serotonergic involvement/
Access Type
Open Access
Document Type
thesis
Degree Program
Psychology
Degree Name
Thesis (M.S.)
Year Degree Awarded
1981
Abstract
The first drug to be found useful in suppressing appetite was amphetamine (Lesser and Meyerson, 1938). Amphetamine has potent central stimulant, cardiovascular, hyperthermic and anorectic properties, to all of which tolerance develops upon repeated use. The need for a more selective anorectic drug without the dangers of abuse and toxicity prompted numerous studies into the anorectic activity of a number of related compounds, all based upon the phenethylamine molecule. This led to the development of fenfluramine l-(3-trifluoromethylphenyl)-2-ethylaminopropane (Alphin et al., 1964). Fenfluramine provided the appetite suppression characteristic of amphetamine without producing the central stimulation.
DOI
https://doi.org/10.7275/j0fb-fd83