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Thesis (M.S.)

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Chlordiazepoxide, Psychopharmacology, Depression, Mental


Two opposing effects on "behavior, a depressant effect and a disinhibitory effect, have been attributed to the "benzodiazepine tranquillizers including chlordiazepoxide. The depressant effect has "been reported to undergo tolerance with repeated doses over several days. The first experiment here was designed to determine the number of days required for tolerance at the 15 mg/kg dose. When no tolerance was found in a test of spontaneous activity, further studies were conducted to determine why no tolerance had occurred and to study conditions under which tolerance might be found.