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Access Type
Open Access
Document Type
thesis
Degree Program
Public Health
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2012
Month Degree Awarded
September
Keywords
gestational diabetes mellitus, GDM, cord blood lipids, prospective, maternal lipids, cardiometabolic risk GDM
Abstract
Gestational diabetes mellitus (GDM), a pregnancy-induced metabolic disorder that affects 2-10% of pregnancies poses future risk for diabetes mellitus (DM) and cardiovascular disease in mother and child. However, few prospective studies have examined the effect of GDM on altered maternal and cord blood lipids, specifically HDL, LDL, triglycerides, and total cholesterol, both during and after pregnancy. We have evaluated the association between GDM and lipid metabolism in pregnant mothers and their infants using data from a prospective cohort study conducted at Baystate Medical Center’s Wesson Women and Infant’s Unit. GDM was assessed prenatally by 3-hr GTT blood samples and was confirmed by obstetrician review. Lipids were assessed via fasting and non-fasting blood samples obtained during 3-hr GTTs performed at 24-28 weeks of gestation and 6-8 weeks post-partum. Data for covariates were collected via an interview form administered at the time of recruitment. We used multivariable linear regression to evaluate the association between GDM status and maternal lipids during and after pregnancy as well as cord lipids. These study results inform future research on GDM as a risk factor for future metabolic disorders in mother and child.
DOI
https://doi.org/10.7275/3284800
First Advisor
Brian W. Whitcomb
Second Advisor
Lisa Chasan-Taber
Included in
Circulatory and Respiratory Physiology Commons, Clinical Epidemiology Commons, Epidemiology Commons, Other Public Health Commons