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SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) AS AN APPROACH FOR THE EMERGING LIQUID BIOPSY DIAGNOSTICS
Author ORCID Identifier
https://orcid.org/0000-0002-9230-7514
AccessType
Open Access Dissertation
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Mechanical Engineering
Year Degree Awarded
2021
Month Degree Awarded
May
First Advisor
Byung Kim
Second Advisor
Yubing Sun
Subject Categories
Biological Engineering | Biomedical Devices and Instrumentation | Other Biomedical Engineering and Bioengineering
Abstract
Large Molecule bioanalysis and biosensor development are essential techniques that are required in many applications, including biotherapeutic development, in vitro diagnostic, biomarker detection, and early detection. These techniques should be highly specific and sensitive enough to identify and quantify an analyte of interest with minimum sample pretreatment requirements. This work explores the development and application of chip-scale bioassays based on surface-enhanced Raman scattering (SERS). It introduces sensing techniques to quantify various disease biomarkers, specifically pancreatic cancer. Blood is the best source of information about our body's function. There are many biomarkers in the blood, and each biomarker's high expression level can be referred to as a specific disorder. In this work, we have developed sensitive detecting methods to quantify these biomarkers. We successfully validated this method with human serum samples. Due to its capability to detect multiple biomarkers, the proposed bioanalytical technique can enhance the specificity of the approach enabled by machine learning based data classification algorithm.
DOI
https://doi.org/10.7275/21466777.0
Recommended Citation
Banaei, Nariman, "SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) AS AN APPROACH FOR THE EMERGING LIQUID BIOPSY DIAGNOSTICS" (2021). Doctoral Dissertations. 2161.
https://doi.org/10.7275/21466777.0
https://scholarworks.umass.edu/dissertations_2/2161
Included in
Biological Engineering Commons, Biomedical Devices and Instrumentation Commons, Other Biomedical Engineering and Bioengineering Commons