Research reported here relates to comparing the relative effectiveness of 320-kV X rays compared to Cs-137 gamma rays for two in vivo endpoints in C.B-17 mice after whole-body exposure: (1) cytotoxicity to bone marrow cells and splenocytes evaluated at 24-hours post exposure and (2) bone marrow and spleen reconstitution deficits (repopulation short- falls) evaluated at 6 weeks post exposure. We show that cytotoxicity dose-response rela- tionships for bone marrow cells and splenocytes are complex, involving negative curvature (decreasing slope as dose increases), presumably implicating a mixed cell population com- prised of large numbers of hypersensitive, modestly radiosensitive, and resistant cells. The radiosensitive cells appear to respond with 50% being killed by a dose < 0.5 Gy. The X-ray relative biological effectiveness (RBE), relative to gamma rays, for destroying bone mar- row cells in vivo is > 1, while for destroying splenocytes it is < 1. In contrast, dose-response relationships for reconstitution deficits in the bone marrow and spleen of C.B-17 mice at 6 weeks after radiation exposure were of the threshold type with gamma rays being more effective in causing reconstitution deficit.
Scott, B.R.; Gott, K.M.; Potter, C.A.; and Wilder, J.
"A COMPARISON OF IN VIVO CELLULAR RESPONSES TO CS-137 GAMMA RAYS AND 320-KV X RAYS,"
Dose-Response: An International Journal: Vol. 11
, Article 3.
Available at: http://scholarworks.umass.edu/dose_response/vol11/iss4/3