Some people in different parts of Iran use burned mantles as a wound healing medicine. To perform surface area measurement, twenty rats were divided randomly into two groups of 10 animals each. The 1st group received topical burned radioactive lantern mantle powder at 1st-3rd day after making excision wounds. The 2nd group received nonradioactive lantern mantle powder. For histological study, 36 male rats randomly divided into two groups of 18 animals each. Full thickness excision wound (314±31.4 mm2) was made on the dorsal neck in all animals after inducing general anesthesia. For the first 3 days, cases received topical application of the radioactive lantern mantle powder. Finally, to measure the tensile strength, an incision was made on the dorsal neck of the rats. Surface area measurement of the wounds showed a progressive surface reduction in both groups. Histological study showed a significant statistically difference between cases and controls with respect to fibrinoid necrosis and neutrophilic exudate at the days 3 and 14. Considering the existence of granulation tissue, a significant difference was observed between case and control groups at days 3 and 7. Tensile strength study showed no significant difference between the cases and controls until 30 days after excision.
Mortazavi, SMJ; Rahmani, MR; Rahnama, A; Saeed-Pour, A; Nouri, E; Hosseini, N; and Aghaiee, MM
"THE STIMULATORY EFFECTS OF TOPICAL APPLICATION OF RADIOACTIVE LANTERN MANTLE POWDER ON WOUND HEALING,"
Dose-Response: An International Journal:
2, Article 4.
Available at: http://scholarworks.umass.edu/dose_response/vol7/iss2/4