ScholarWorks@UMassAmherst

Recent Submissions

  • PublicationOpen Access
    Puncture Characterization of Biological and Bio-Inspired Materials: Custom Literature Survey Database
    (Oxford University Press, 2026-03-27) Quigley, Jennifer; Moreira Lana, Gabriela; Crosby, Alfred
    This dataset compiles puncture mechanics data from the soft matter and biomechanics literature, aggregating results across a wide range of biological tissues and synthetic hydrogels. For each material, the database records material name/type, probe geometry (tip radius, shape, and angle), sample geometry (width/radius, length, thickness), puncture descriptors (puncture force, puncture depth, etc.), probe velocity, and elastic modulus, along with associated standard deviations where reported. The dataset is intended to support the development and validation of scaling relationships governing soft material puncture, and to serve as a reference for researchers working on the mechanical characterization of soft tissues and hydrogels or related applications.
  • PublicationOpen Access
    Native Plants, Plant Movement, and Climate Change Comic (K-5)
    (2026) Nuhfer, Thomas
    Native plants evolve over time to have deep, specialized relationships in their environments. Movement due to changing environmental conditions is a normal part of that process. However, as humans move plants around, and change our ecosystems in other ways, we may outpace our ecosystems' abilities to keep up. This short comic provides an introduction to native plants and introduced plants, and explains why some plant introductions may lead to ecological imbalance (and be considered "invasive"). It also explores the impacts of climate change on plant communities. This is intended to be used as an educational resource for children K-5 (written for an approximately 3rd grade level). It includes glossary and discussion pages, though an art-page only version is also included.
  • PublicationOpen Access
    Hydrological Cycle Intensification and Permafrost Thaw Drive Increased Freshwater and Organic Carbon Inputs to Northern Alaska Estuaries
    (2026) Rawlins, Michael; Connolly, Craig; McClelland, James W
    Understanding how hydrological inflows and climate change influence individual estuaries across northern Alaska is limited by a paucity of measured data, necessitating the application of suitably scaled numerical process models. This study uses an updated model to quantify freshwater discharge and dissolved organic carbon (DOC) export from the North Slope of Alaska (NSA) to coastal waters of the Beaufort Sea and examines climate-linked temporal changes. The model was applied at 1 km resolution across the 166,483 square kilometer NSA domain over 1980–2023. Watershed inputs to coastal waters were estimated by routing along river networks to 1,039 outlets at the land-sea boundary. Key simulation parameters were evaluated to demonstrate model efficacy, then spatial and temporal patterns were quantified. Exports to specific lagoons, bays, and sounds demonstrate how landscape composition, terrestrial drainage basin size, and estuary area modulate watershed influence on coastal ecosystems across the region. Freshwater discharge and DOC export increased over the greater than four decades, associated with changes in precipitation and permafrost thaw. Surface and supra-permafrost subsurface fluxes also increased, with pronounced rises in proportional contributions via subsurface flow during summer and autumn. These changes have the potential to substantially impact salinity and trophic conditions along Alaska's Beaufort Sea coast. Our study highlights the value of model-data syntheses that resolve regional-to-local scale fluxes where observational measurements are sparse, and provides novel quantitative export metrics that will be useful to researchers, resource managers, and other stakeholders with interests in the climate, hydrology, and biogeochemistry of coastal northern Alaska.
  • PublicationOpen Access
    Electronic cigarettes for smoking cessation: An overview of systematic reviews and evidence and gap map
    (2026-03) Wu, Angela Difeng; Conde, Monserrat; Butler, Ailsa; Knight, Ethan; Lindson, Nicola; Livingstone-Banks, Jonathan; Hajek, Peter; McRobbie, Hayden; Begh, Rachna; Theodoulou, Annika; Notley, Caitlin; Turner, Tari; Zhitnik, Eliza; Hartmann-Boyce, Jamie
    Background and aims Electronic cigarettes (EC) are considered a smoking cessation tool in some countries, such as the United Kingdom, but uncertainty remains internationally over whether their benefits outweigh potential harms when used for this purpose. This overview (1) synthesised existing evidence from systematic reviews (SR) on the effectiveness and safety of ECs to explore and address these uncertainties and disagreements and (2) mapped primary intervention studies to identify priorities for further research. Methods Overview of SRs published from 1 January 2015 and meeting the inclusion criteria of the Cochrane review of EC for smoking cessation. We searched seven databases to April 2024. We followed Cochrane screening and data extraction methods. We adapted Campbell Collaboration and 3ie methods for the Evidence and Gap Map (EGM). We assessed review quality using AMSTAR-2. Results We included 14 reviews of intervention studies (7 high quality; 7 low quality), with search dates from 2014 to 2023, in adult populations including the general population, people at risk of lung cancer, with comorbid health conditions and pregnant people. Eighteen studies were included across multiple reviews, some of which included multiple meta-analyses. Across 21 meta-analytic comparisons of nicotine EC versus other interventions, all reported point estimates favouring nicotine EC for smoking cessation, with relative risks/odds ratios typically in the range 1.17–1.67 versus nicotine replacement therapy and 1.46–2.09 versus non-nicotine EC, with higher-quality reviews giving more consistent estimates. Of 13 reviews that meta-analysed serious adverse events (SAEs), two reported point estimates suggesting increased SAEs with nicotine EC; other estimates included the possibility of no difference. For adverse events, pooled estimates generally indicated little or no difference between groups. Our EGM mapped 90 primary, complete studies and identified absolute gaps in evidence comparing the effects of nicotine EC to cytisine, bupropion and nicotine pouches. Most studies used collected data from high-income countries. Conclusion Meta-analyses of electronic cigarettes (EC) for smoking cessation report point estimates favouring higher ≥6-month smoking cessation rates with nicotine EC compared with nicotine replacement therapy, non-nicotine EC/placebo, behavioural or no support and mixed support. Evidence on serious adverse events (SAEs) remains inconclusive. Evidence gaps were identified in SAE data and in studies from low- and middle-income countries.
  • PublicationOpen Access
    Tuning Protein Uptake through Charge and Hydrophobicity in Peptide-Based Complex Coacervates
    (2026) Sathyavageeswaran, Arvind; Izzo, Mayayi; Bonesso Sabadini, Júlia; Habeeba, Umme; Belden, Jacob; Perry, Sarah
    Protein encapsulation holds considerable promise for applications spanning the food, pharmaceuticals, biocatalysis, and personal care industries. Complex coacervation─an associative liquid–liquid phase separation (LLPS) process─has recently emerged as an effective strategy for achieving high protein loading while maintaining protein structure and function. In this work, we systematically investigate the influence of the coacervate-forming peptide charge density, charge patterning, and hydrophobicity on the partitioning of two model proteins: hen egg white lysozyme (HEWL) and bovine serum albumin (BSA). Using a rationally designed library of synthetic polypeptides, we demonstrate that protein uptake is highly sensitive to both the sequence features and hydrophobicity of the peptides, as well as the surface charge characteristics of the protein cargo. In particular, the localized charge patches on HEWL were sensitive to peptide charge density and patterning, while the hydrophobic character of BSA resulted in preferential partitioning into more hydrophobic coacervates. These findings highlight the critical role of spatial charge distribution and sequence composition in governing protein–coacervate interactions, offering new design principles for tailoring coacervate systems for bioencapsulation and related applications.