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Document Type

Campus-Only Access for Five (5) Years

Degree Name

Doctor of Philosophy (PhD)

Degree Program

Electrical and Computer Engineering

Year Degree Awarded

2016

Month Degree Awarded

May

First Advisor

Christopher D. Salthouse

Second Advisor

Robert W. Jackson

Third Advisor

Deepak K. Ganesan

Subject Categories

Bioimaging and Biomedical Optics | Biomedical | Biomedical Devices and Instrumentation | Electrical and Electronics | VLSI and Circuits, Embedded and Hardware Systems

Abstract

Modern laboratory equipments to measure the excited-state lifetime of fluorophores usually include an expensive picosecond pulsed-laser excitation source, a fragile photomultiplier tube, and a large instrument body for optics. A portable and robust device to make fluorescence lifetime measurement in nanosecond scale is of great attraction for chemists and biologists.

This dissertation reports the development of a portable LED time-domain fluorimeter from an all-solid-state discrete-component prototype to its advanced CMOS integrated circuit implementation. The motivation of the research is to develop a multiplexed fluorimeter for point-of-care diagnosis. Instruments developed by this novel method have higher fill factor, are more portable, and are fabricated at lower cost.

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