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Author ORCID Identifier
Open Access Dissertation
Doctor of Philosophy (PhD)
Electrical and Computer Engineering
Year Degree Awarded
Month Degree Awarded
Christopher D. Salthouse
Robert W. Jackson
Deepak K. Ganesan
Bioimaging and Biomedical Optics | Biomedical | Biomedical Devices and Instrumentation | Electrical and Electronics | VLSI and Circuits, Embedded and Hardware Systems
Modern laboratory equipments to measure the excited-state lifetime of fluorophores usually include an expensive picosecond pulsed-laser excitation source, a fragile photomultiplier tube, and a large instrument body for optics. A portable and robust device to make fluorescence lifetime measurement in nanosecond scale is of great attraction for chemists and biologists.
This dissertation reports the development of a portable LED time-domain fluorimeter from an all-solid-state discrete-component prototype to its advanced CMOS integrated circuit implementation. The motivation of the research is to develop a multiplexed fluorimeter for point-of-care diagnosis. Instruments developed by this novel method have higher fill factor, are more portable, and are fabricated at lower cost.
Wang, Hongtao, "Development of a Portable CMOS Time-Domain Fluorescence Lifetime Imager" (2016). Doctoral Dissertations. 670.
Bioimaging and Biomedical Optics Commons, Biomedical Commons, Biomedical Devices and Instrumentation Commons, Electrical and Electronics Commons, VLSI and Circuits, Embedded and Hardware Systems Commons