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Open Access Thesis
Neuroscience & Behavior
Master of Science (M.S.)
Year Degree Awarded
Month Degree Awarded
Ciprofloxacin is a widely prescribed antibiotic which causes idiopathic sensory adverse effects and is known to induce oxidative stress. Dopaminergic cells are known to have intrinsic sensitivity to oxidative stress. To investigate whether ciprofloxacin potentiates cy- totoxicity of dopamine, effects of combined drug treatments on cell viability were assessed by resazurin reduction, and effects on mitochondrial health were assessed by morphology. The cell viability assays suggest that ciprofloxacin significantly potentiates dopamine cytotoxicity at clinically relevant doses, although dopamine possibly interferes with the viability assay. Effects of drug treatments on mitochondrial morphology were inconclusive.
James J Chambers
Johnson, Jeffreys N., "INVESTIGATING EFFECTS OF THE ANTIBIOTIC CIPROFLOXACIN ON THE DOPAMINERGIC SH-SY5Y CELL LINE" (2015). Masters Theses. 275.