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ORCID
N/A
Access Type
Open Access Thesis
Document Type
thesis
Degree Program
Molecular & Cellular Biology
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2016
Month Degree Awarded
May
Abstract
Microtubules are the most rigid element of the cytoskeleton. They are responsible for the structure of cells and make up the tracks for intracellular cargo transport. Interactions between microtubules, motor proteins, and microtubule-associated proteins drive important mechanisms in the cell, such as cell division, cell motility, cell homeostasis, and cell signaling. I seek to understand how such complex, energy-consuming non-equilibrium biological networks self-organize by studying in vitro microtubules bundled by microtubule-associated protein 65 (MAP65), in kinesin-1 gliding assays. I found that large networks can break into smaller, cell-like networks that can mimic types of cell motility. Dynamics of these networks change with varying concentrations of MAP65 and microtubules.
DOI
https://doi.org/10.7275/8615027
First Advisor
Jennifer L Ross
Second Advisor
Edward P Debold
Third Advisor
Maria Milfoil
Recommended Citation
Stanhope, Kasimira T., "Dynamics of Microtubule Networks with Antiparallel Crosslinkers" (2016). Masters Theses. 376.
https://doi.org/10.7275/8615027
https://scholarworks.umass.edu/masters_theses_2/376