Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity

Authors

Semra Colak, University of Massachusetts Amherst
Christopher F. Nelson, University of Massachusetts Amherst
Klaus Nüsslein, University of Massachusetts Amherst
Gregory N. Tew, University of Massachusetts Amherst

Publication Date

2009

Journal or Book Title

Biomacromolecules

Abstract

Here, we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and post-polymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC₅₀).

DOI

https://doi.org/10.1021/bm801129y

Pages

353-359

Volume

10

Issue

2

Recommended Citation

Colak, Semra; Nelson, Christopher F.; Nüsslein, Klaus; and Tew, Gregory N., "Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity" (2009). Biomacromolecules. 991.
https://doi.org/10.1021/bm801129y