Publication Date
2021
Journal or Book Title
JOURNAL OF BIOLOGICAL CHEMISTRY
Abstract
This collection of articles celebrates the 50th anniversary of the Protein Data Bank (PDB), the single global digital archive of biological macromolecular structures. The impact of the PDB is immense; we have invited a number of top researchers in structural biology to illustrate its influence on an array of scientific fields. What emerges is a compelling picture of the synergism between the PDB and the explosive progress witnessed in many scientific areas. Availability of reliable, openly accessible, well-archived structural information has arguably had more impact on cell and molecular biology than even some of the enabling technologies such as PCR. We have seen the science move from a time when structural biologists contributed the lion's share of the structures to the PDB and for discussion within their community to a time when any effort to achieve in-depth understanding of a biochemical or cell biological question demands an interdisciplinary approach built atop structural underpinnings.
ORCID
Gierasch, Lila/0000-0002-5706-115X
DOI
https://doi.org/10.1016/j.jbc.2021.100608
Volume
296
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Funder
NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R35 GM118161]
Recommended Citation
Berman, Helen M. and Gierasch, Lila M., "How the Protein Data Bank Changed Biology: An Introduction to The JBC Reviews Thematic Series, Part 1" (2021). JOURNAL OF BIOLOGICAL CHEMISTRY. 23.
https://doi.org/10.1016/j.jbc.2021.100608