Publication Date
2019
Journal or Book Title
Biology
Abstract
The primary goal of cytokinesis is to produce two daughter cells, each having a full set of chromosomes. To achieve this, cells assemble a dynamic structure between segregated sister chromatids called the contractile ring, which is made up of filamentous actin, myosin-II, and other regulatory proteins. Constriction of the actomyosin ring generates a cleavage furrow that divides the cytoplasm to produce two daughter cells. Decades of research have identified key regulators and underlying molecular mechanisms; however, many fundamental questions remain unanswered and are still being actively investigated. This review summarizes the key findings, computational modeling, and recent advances in understanding of the molecular mechanisms that control the formation of the cleavage furrow and cytokinesis
DOI
https://doi.org/10.3390/biology8030055
Volume
8
Issue
3
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Verma, Vikash; Mogilner, Alex; and Maresca, Thomas J., "Classical and Emerging Regulatory Mechanisms of Cytokinesis in Animal Cells" (2019). Biology. 646.
https://doi.org/10.3390/biology8030055