Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes

Authors

Khachatur Julfakyan, King Abdullah University of Science and Technology
Yevhen Fatieiev, King Abdullah University of Science and Technology
Shahad Alsaiari, King Abdullah University of Science and Technology
Lin Deng, King Abdullah University of Science and Technology
Alaa Ezzeddine, King Abdullah University of Science and Technology
Dingyuan Zhang, Chinese Academy of Sciences
Vincent M. Rotello, University of Massachusetts AmherstFollow
Niveen M. Khashab, King Abdullah University of Science and Technology

Publication Date

2015

Journal or Book Title

International Journal of Molecular Sciences

Abstract

Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm² power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity.

DOI

https://doi.org/10.3390/ijms160818283

Volume

16

Special Issue

Developmental and Reproductive Toxicity of Iron Oxide Nanoparticles

Issue

8

License

UMass Amherst Open Access Policy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

Julfakyan, Khachatur; Fatieiev, Yevhen; Alsaiari, Shahad; Deng, Lin; Ezzeddine, Alaa; Zhang, Dingyuan; Rotello, Vincent M.; and Khashab, Niveen M., "Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes" (2015). International Journal of Molecular Sciences. 1465.
https://doi.org/10.3390/ijms160818283