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Interaction of amphiphilic macromolecules with globular proteins

Britto S Sandanaraj, University of Massachusetts Amherst


The application of bionanotechnology in medicine has tremendously increased over past three decades. The role of synthetic polymer/supramolecular chemistry has proven to be a key component in this multidisciplinary research. Towards that direction, this thesis work describes the entry of our group research in the area of “applications of custom designed amphiphilic macromolecules in medicine or biology”. We have successfully used our amphiphilic homopolymer scaffold to recognize, bind and modulate the function of the proteins. The proof of concept was demonstrated using two proteins, chymotrypsin and cytochrome c. Further, We have also synthesized water-soluble fluorescent organic nanosensors by functionalizing the amphiphilic polymers with appropriate organic dye. These fluorescent nanosensors have been effectively used to detect the presence of metalloproteins in the presence of nonmetalloproteins. Along that direction, we have also utilized our scaffold to detect a particular metalloproteins by creating pattern using Stern-Volmer quenching studies.

Subject Area

Organic chemistry

Recommended Citation

Sandanaraj, Britto S, "Interaction of amphiphilic macromolecules with globular proteins" (2007). Doctoral Dissertations Available from Proquest. AAI3289226.