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Author ORCID Identifier

https://orcid.org/0000-0001-8956-1581

AccessType

Campus-Only Access for Five (5) Years

Document Type

dissertation

Degree Name

Doctor of Philosophy (PhD)

Degree Program

Chemistry

Year Degree Awarded

2021

Month Degree Awarded

September

First Advisor

S. Thayumanavan

Subject Categories

Materials Chemistry | Nanomedicine | Polymer Chemistry

Abstract

Cancer treatment by chemotherapeutics often results in off-target effects. To minimize the adverse effects of chemotherapy, multiple ways of achieving targeted drug delivery have evolved. Antibody-drug conjugates (ADCs) are one such class of drugs. However, development of new ADCs is challenging and not generalizable. In this dissertation, we utilize antibody-nanoparticle conjugates (ANCs) to address the limitations of ADCs as well as to develop a platform technology toward achieving targeted delivery of chemotherapeutics to cancer cells. In this dissertation, we have also set the groundwork for utilizing proteins/antibodies as drugs for cancer therapy. Two different nanoparticle systems were developed for (a) achieving targeted delivery of proteins to cancer cells selectively and (b) efficient intracellular delivery of large proteins such as antibodies. Extending the applicability of antibody-conjugated polymeric nanoparticle, anionic polymer-antibody conjugates were formulated for developing a technique to achieve targeted electroporation of biologics into cancer cells.

DOI

https://doi.org/10.7275/24358572

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Available for download on Thursday, September 01, 2022

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