Off-campus UMass Amherst users: To download campus access dissertations, please use the following link to log into our proxy server with your UMass Amherst user name and password.
Non-UMass Amherst users: Please talk to your librarian about requesting this dissertation through interlibrary loan.
Dissertations that have an embargo placed on them will not be available to anyone until the embargo expires.
Author ORCID Identifier
https://orcid.org/0000-0002-1535-9804
AccessType
Open Access Dissertation
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Chemistry
Year Degree Awarded
2023
Month Degree Awarded
September
First Advisor
Vincent Rotello
Second Advisor
Michael Knapp
Third Advisor
Eric Strieter
Fourth Advisor
Ashish Kulkarni
Subject Categories
Nanomedicine
Abstract
Bioorthogonal chemistry has emerged as a promising strategy for regulating bioprocesses through abiotic reactions. Bioorthogonal unmasking reactions mediated by transition metal catalysts (TMCs) present a powerful tool for biomedical applications due to their ability to generate therapeutic agents in situ, minimizing off-target effects. However, the direct application of TMC-mediated reactions in a biological environment poses challenges due to limited water solubility and biocompatibility of these catalysts. My Ph.D. research focused on encapsulating TMCs into polymer nanoparticles to obtain bioorthogonal nanocatalysts. These nanoscaffolds solubilize and stabilize hydrophobic catalyst molecules while preserving catalytic activity and stability in complex biological media. Furthermore, by varying their structure design and/or formulation strategies, these nanocatalysts provided enhanced biocompatibility while enabling controlled drug release for imaging and therapeutic applications.
DOI
https://doi.org/10.7275/35932699
Recommended Citation
Huang, Rui, "Polymer-Based Bioorthogonal Nanocatalysts for Bacterial Biofilm Treatment" (2023). Doctoral Dissertations. 2991.
https://doi.org/10.7275/35932699
https://scholarworks.umass.edu/dissertations_2/2991
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License