Publication Date
2021
Journal or Book Title
International Journal of Molecular Sciences
Abstract
Severe outcomes of COVID-19 are associated with pathological response of the immune system to the SARS-CoV-2 infection. Emerging evidence suggests that an interaction may exist between COVID-19 pathogenesis and a broad range of xenobiotics, resulting in significant increases in death rates in highly exposed populations. Therefore, a better understanding of the molecular basis of the interaction between SARS-CoV-2 infection and chemical exposures may open opportunities for better preventive and therapeutic interventions. We attempted to gain mechanistic knowledge on the interaction between SARS-CoV-2 infection and chemical exposures using an in silico approach, where we identified genes and molecular pathways affected by both chemical exposures and SARS-CoV-2 in human immune cells (T-cells, B-cells, NK-cells, dendritic, and monocyte cells). Our findings demonstrate for the first time that overlapping molecular mechanisms affected by a broad range of chemical exposures and COVID-19 are linked to IFN type I/II signaling pathways and the process of antigen presentation. Based on our data, we also predict that exposures to various chemical compounds will predominantly impact the population of monocytes during the response against COVID-19.
DOI
https://doi.org/10.3390/ijms222212474
Special Issue
Applications of Computational Modeling in Disease, Infection and Drug Design
Volume
22
Issue
22
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Arowolo, Olatunbosun; Pobezinsky, Leonid; and Suvorov, Alexander, "Chemical Exposures Affect Innate Immune Response to SARS-CoV-2" (2021). International Journal of Molecular Sciences. 29.
https://doi.org/10.3390/ijms222212474