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Dynamics of Microtubule Networks with Antiparallel Crosslinkers

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dc.contributor.advisorJennifer L Ross
dc.contributor.advisorEdward P Debold
dc.contributor.advisorMaria Milfoil
dc.contributor.authorStanhope, Kasimira T
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentMolecular & Cellular Biology
dc.date2024-03-28T19:50:55.000
dc.date.accessioned2024-04-26T18:19:21Z
dc.date.available2024-04-26T18:19:21Z
dc.date.submittedMay
dc.date.submitted2016
dc.description.abstractMicrotubules are the most rigid element of the cytoskeleton. They are responsible for the structure of cells and make up the tracks for intracellular cargo transport. Interactions between microtubules, motor proteins, and microtubule-associated proteins drive important mechanisms in the cell, such as cell division, cell motility, cell homeostasis, and cell signaling. I seek to understand how such complex, energy-consuming non-equilibrium biological networks self-organize by studying in vitro microtubules bundled by microtubule-associated protein 65 (MAP65), in kinesin-1 gliding assays. I found that large networks can break into smaller, cell-like networks that can mimic types of cell motility. Dynamics of these networks change with varying concentrations of MAP65 and microtubules.
dc.description.degreeMaster of Science (M.S.)
dc.identifier.doihttps://doi.org/10.7275/8615027
dc.identifier.orcidN/A
dc.identifier.urihttps://hdl.handle.net/20.500.14394/33383
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1426&context=masters_theses_2&unstamped=1
dc.source.statuspublished
dc.subjectMicrotubule
dc.subjectMAP65
dc.subjectKinesin-1
dc.subjectBiophysics
dc.titleDynamics of Microtubule Networks with Antiparallel Crosslinkers
dc.typeopenaccess
dc.typearticle
dc.typethesis
digcom.contributor.authorisAuthorOfPublication|email:kstanhop@umass.edu|institution:University of Massachusetts Amherst|Stanhope, Kasimira T
digcom.identifiermasters_theses_2/376
digcom.identifier.contextkey8615027
digcom.identifier.submissionpathmasters_theses_2/376
dspace.entity.typePublication
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