This dissertation studies contemporary Latinx literature and visual arts, with a focus on Afro-Dominican, Chicanx, and U.S. Central American writers and artists. It explores the construction of identity and subjectivity under intersectional racial trauma and other forms of wounding caused by systemic oppression and exploitation. This transdisciplinary project puts forth the conceptual paradigm of the wound to study representation of harm and damage—physical, psychological, and spiritual—in prominent Latinx literary and artistic works. By centering on the overlapping violences of colonialism, racism, and (hetero)sexism, it advances a decolonial approach to underline the role of Latinx literature and visual culture as catalysts for personal, political, and social transformation and healing. “Manifestations of the Wound” contributes to broader discussions in Latinx studies, decolonial (trauma) studies, and critical ethnic studies, addressing topics such as the disruption of Western biomedical and secular notions of wellness and the legitimization of intersectional analyses of oppression. This dissertation contests philosophical and theoretical trends dictated by White supremacy, Eurocentrism, and Enlightened Humanism. It also proposes open, expansive, and dialogic methodologies for studying Latinx literature and arts, challenging Western hegemonic thinking and addressing colonial legacies such as the body/mind split. This project offers new interpretations of the works of queer Chicanx writers like Gloria Anzaldúa and Rigoberto González, as well as poet Yesika Salgado. Additionally, it examines the art of Afro-Latinx visual artists, including Dominican Americans Firelei Báez and Bony Ramirez, who highlight the wounding and erasure of Black, Afro-descendant, and Indigenous peoples from the annals of U.S. and Caribbean histories. The first chapter examines corporeal subjectivities in the life-writings of Chicano gay memoirist Rigoberto González and Salvadoran American poet Yesika Salgado. The second chapter broadens the corpus of creative works addressing the Juárez feminicide crisis by analyzing Latinx creative responses from the North, such as the plays of Marisela Treviño-Orta’s Braided Sorrow (2005) and Isaac Gómez’s La Ruta (2019) as well as the visual production of Judithe Hernández's Juárez Series (2011-). These representations of feminicide advocate for the healing of this social crisis by enacting an ethics of interconnectedness that brings attention to the repercussions of feminicide on the U.S.-Mexico border. The third chapter presents new scholarship on Gloria Anzaldúa’s archived artwork, analyzing her sketches and glifos to highlight their decolonial potential, but, most importantly, to elucidate Anzaldúa’s healing process through the use of multidimensional techniques and imagination. The fourth chapter explores decolonial imaginaries imbued with an aesthetics of fugitivity and Afro-resistance, highlighting the healing collective endeavors in the works of Firelei Báez and Bony Ramirez. It addresses the wounds of coloniality, using these imaginaries as antidotes and tactics to suture the wounds of the past, such as the Middle Passage and the enslavement of Africans and Afrodiasporic subjects. This research ultimately offers new ways of understanding Latinx literature and visual arts, emphasizing their roles in fostering intersectional, antiracist, and decolonial frameworks. Through close-readings and visual analysis, this projects concludes that the manifestation and rendering of wounds by these artists and writers is a collective endeavor and a distinctive feature of Latinx letters and visual arts. This decolonial healing process, far from perpetuating static narratives of Latinidad, serves as a mechanism of resistance with liberatory capacities. Therefore, this project seeks to showcase a diverse and growing body of Latinx works that underpin a range of ways in which literature and art can penetrate and mobilize the political and social sphere. In so doing, Latinx literature and visual arts are also framed as sources we can tap to remedy problems such as racial and transgenerational trauma, illnesses, and physical deterioration, normally the concerns of social and medical science research.