Food-grade cationic antimicrobial ε-polylysine transiently alters the gut microbial community and predicted metagenome function in CD-1 mice

You, Xiaomeng; Einson, Jonah E.; Lopez-Pena, Cynthia Lyliam; Song, Mingyue; Xiao, Hang; McClements, David Julian; Sela, David

Publication:
Food-grade cationic antimicrobial ε-polylysine transiently alters the gut microbial community and predicted metagenome function in CD-1 mice

dc.contributor.author	You, Xiaomeng
dc.contributor.author	Einson, Jonah E.
dc.contributor.author	Lopez-Pena, Cynthia Lyliam
dc.contributor.author	Song, Mingyue
dc.contributor.author	Xiao, Hang
dc.contributor.author	McClements, David Julian
dc.contributor.author	Sela, David
dc.contributor.department	University of Massachusetts Amherst
dc.contributor.department	University of Massachusetts Amherst
dc.contributor.department	University of Massachusetts Amherst
dc.contributor.department	University of Massachusetts Amherst
dc.contributor.department	University of Massachusetts Amherst
dc.contributor.department	University of Massachusetts Amherst
dc.contributor.department	University of Massachusetts Amherst
dc.date	2023-09-23T19:53:51.000
dc.date.accessioned	2024-04-26T17:31:43Z
dc.date.available	2018-01-08T00:00:00Z
dc.date.issued	2017-01-01
dc.description.abstract	Diet is an important factor influencing the composition and function of the gut microbiome, but the effect of antimicrobial agents present within foods is currently not understood. In this study, we investigated the effect of the food-grade cationic antimicrobial ε-polylysine on the gut microbiome structure and predicted metagenomic function in a mouse model. The relative abundances of predominant phyla and genera, as well as the overall community structure, were perturbed in response to the incorporation of dietary ε-polylysine. Unexpectedly, this modification to the gut microbiome was experienced transiently and resolved to the initial basal composition at the final sampling point. In addition, a differential non-random assembly was observed in the microbiomes characterized from male and female co-housed animals, although their perturbation trajectories in response to diet remain consistent. In conclusion, antimicrobial ε-polylysine incorporated into food systems transiently alters gut microbial communities in mice, as well as their predicted function. This indicates a dynamic but resilient microbiome that adapts to microbial-active dietary components.
dc.identifier.doi	10.1038/s41538-017-0006-0
dc.identifier.orcid	0000-0002-3354-7470
dc.identifier.uri	https://hdl.handle.net/20.500.14394/29638
dc.relation.ispartof	npj Science of Food
dc.relation.url	https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1007&context=foodsci_faculty_pubs&unstamped=1
dc.rights	UMass Amherst Open Access Policy
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.source.issue	1
dc.source.status	published
dc.subject	applied microbiology
dc.subject	microbiota
dc.subject	Food Science
dc.title	Food-grade cationic antimicrobial ε-polylysine transiently alters the gut microbial community and predicted metagenome function in CD-1 mice
dc.type	article
dc.type	article
digcom.contributor.author	You, Xiaomeng
digcom.contributor.author	Einson, Jonah E.
digcom.contributor.author	Lopez-Pena, Cynthia Lyliam
digcom.contributor.author	Song, Mingyue
digcom.contributor.author	Xiao, Hang
digcom.contributor.author	McClements, David Julian
digcom.contributor.author	isAuthorOfPublication\|email:davidsela@umass.edu\|institution:University of Massachusetts Amherst\|Sela, David
digcom.date.embargo	2018-01-08T00:00:00-08:00
digcom.identifier	foodsci_faculty_pubs/8
digcom.identifier.contextkey	11334180
digcom.identifier.submissionpath	foodsci_faculty_pubs/8
dspace.entity.type	Publication
relation.isAuthorOfPublication	46d5d02f-51c4-436d-ab3e-7c6790a55fef
relation.isAuthorOfPublication.latestForDiscovery	46d5d02f-51c4-436d-ab3e-7c6790a55fef