Publication:
Detrimental Effects of Inactivity on Insulin Action

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dc.contributor.advisorBarry Braun
dc.contributor.advisorPatty S. Freedson
dc.contributor.advisorJohn Staudenmayer
dc.contributor.authorStephens, Brooke Rene
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.date2023-09-22T20:18:55.000
dc.date.accessioned2024-04-26T19:53:27Z
dc.date.available2024-04-26T19:53:27Z
dc.date.issued2009-05-01
dc.description.abstractInactivity reduces insulin action. Energy surplus causes similar reductions to insulin action. Unless energy intake is reduced to match low energy expenditure during inactivity, a concurrent energy surplus may account for the lower insulin action. This study evaluated the effect of inactivity (sitting) with and without energy surplus on insulin action. Fourteen young (26.1 ± 4.5 years (M ± SD)), lean (23.7 ± 7.1% fat), fit (VO 2peak = 49.1 ± 3.3 ml*kg -1 *min -1 ) men (n=7) and women (n=7) completed each of 3, 24-hour conditions: an active condition (i.e. high energy expenditure with energy intake matched to expenditure) = ACTIV; (2) reduced energy expenditure (inactivity) with no reduction in energy intake (i.e. energy surplus) = INACTIV; (3) inactivity with energy intake reduced to match low energy expenditure = INACTIV LO-CAL. Insulin action was measured during a glucose infusion the following morning. Data were analyzed using linear mixed-effects models with planned contrasts. Compared to ACTIV, insulin action, defined as whole-body rate of glucose disappearance ( R d ) scaled to steady-state plasma insulin, was reduced 39% in INACTIV ( p < 0.001) and by 18% in INACTIV LO-CAL ( p = 0.07). Insulin action was also higher in INACTIV LO-CAL compared to INACTIV ( p =0.04). These results suggest that 1 day of sitting elicits large reductions in insulin action. Energy surplus accounts for half of the decline in insulin action, suggesting other factors are involved in the metabolic response to inactivity.
dc.description.degreeDoctor of Philosophy (PhD)
dc.description.departmentKinesiology
dc.identifier.doihttps://doi.org/10.7275/ex1j-2d59
dc.identifier.urihttps://hdl.handle.net/20.500.14394/39182
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1079&amp;context=open_access_dissertations&amp;unstamped=1
dc.source.statuspublished
dc.subjectGlucose uptake
dc.subjectMetabolic health
dc.subjectSitting
dc.subjectInactivity
dc.subjectInsulin
dc.subjectBiochemical Phenomena, Metabolism, and Nutrition
dc.subjectPublic Health
dc.titleDetrimental Effects of Inactivity on Insulin Action
dc.typedissertation
dc.typearticle
dc.typedissertation
digcom.contributor.authorisAuthorOfPublication|email:brstephe@kin.umass.edu|institution:University of Massachusetts Amherst|Stephens, Brooke Rene
digcom.identifieropen_access_dissertations/73
digcom.identifier.contextkey1054085
digcom.identifier.submissionpathopen_access_dissertations/73
dspace.entity.typePublication
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