Associations Between Vitamin D Status, Adiposity, And Inflammatory Biomarkers In Young Women (18 – 30 Years)

Show simplified metadata
dc.contributor.advisorRonnenberg, Alayne
dc.contributor.advisorBertone-Johnson, Elizabeth
dc.contributor.advisorWood, Richard
dc.contributor.advisorBigelow, Carol
dc.contributor.authorAddo-Lartey, Adolphina
dc.contributor.departmentUniversity of Massachusetts Amherst, Public Health
dc.date2023-09-23 10:04:12
dc.date.accessioned2024-04-26T15:29:08Z
dc.date.available2024-04-26T15:29:08Z
dc.date.issued2014
dc.date.submitted2014
dc.description.abstractWe conducted a cross-sectional analysis among 270 (18- to 30-year old) female participants in the UMass Amherst Vitamin D Status Study (n = 270) to assess the extent to which dietary intakes of calcium and vitamin D are associated with obesity markers. We also evaluated the association between serum 25-OHD concentrations and both adiposity and inflammatory biomarkers. Study participants were mostly Caucasians (84.5%) with normal BMI, although about half of women had high adiposity (total body fat ‘TBF’≥ 32%). Women reporting adequate intakes of calcium (≥ 1000 mg/day) but low intakes of vitamin D (< 600 IU/day) were more than twice as likely to have a high percentage of TBF compared to women with adequate intakes of both calcium and vitamin D. In addition, women with lower calcium intake from supplements were twice as likely to have a waist circumference ≥ 80 cm (OR = 2.04; 95% CI: 1.04 – 3.99) compared to women in the highest tertile of calcium intake. The magnitude of this association is important since among young women 18-30 years old, a waist circumference greater than 80 cm indicates central obesity and suggests increased visceral adiposity, which contributes to hyperlipidemia and other obesity-related chronic conditions. Among all women, total vitamin D, food vitamin D, and supplemental vitamin D intake were not associated with serum 25-OHD concentration (P > 0.05). However, among supplement users only, intake of vitamin D supplements was positively correlated with serum 25-OHD levels (ß = 0.03 ± 0.01 nmol/L, P = 0.05). These findings support the notion that serum levels of 25-OHD are influenced by other factors besides the vitamin D content of foods, including the use of vitamin D supplements. Serum 25-OHD concentration tended to be correlated with hs-CRP levels (r = 0.14, P = 0.06), but was not significantly associated with adiposity and inflammatory biomarkers. Among women with low 25-OHD (< 75 nmol/L), serum 25-OHD level was inversely associated with IL-2 and GM-CSF concentrations, and marginally associated with IL-6 and IL-7 concentrations. Additional prospective studies in more heterogeneous populations will help to characterize the relationship between vitamin D status, inflammation and obesity.
dc.description.degreeDoctor of Philosophy (Ph.D.)
dc.description.departmentPublic Health
dc.identifier.doi10.7275/6054079.0
dc.identifier.orcidN/A
dc.identifier.urihttps://hdl.handle.net/20.500.14394/17725
dc.source.statuspublished
dc.subjectCalcium
dc.subjectVitamin D
dc.subjectAdiposity
dc.subjectBody fat percentage
dc.subjectBMI
dc.subjectWaist circumference
dc.subjectSerum 25-hydroxyvitamin D
dc.subjectInflammation
dc.subjectYoung women
dc.subjectPublic Health
dc.subjectWomen's Health
dc.titleAssociations Between Vitamin D Status, Adiposity, And Inflammatory Biomarkers In Young Women (18 – 30 Years)
dc.typeDissertation (Open Access)
digcom.contributor.authorisAuthorOfPublication|email:aaadoley@gmail.com|institution:University of Massachusetts Amherst|Addo-Lartey, Adolphina
digcom.identifierdissertations_2/150
digcom.identifier.contextkey6054079
digcom.identifier.submissionpathdissertations_2/150
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Addo_Lartey_Ph.D._dissertation_Revised.pdf
Size:
4.77 MB
Format:
Adobe Portable Document Format
Download
Collections
Dissertations
Public Health Department Dissertations Collection