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Microfluidics: From Crystallization to Serial Time-Resolved Crystallography

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dc.contributor.authorSui, Shuo
dc.contributor.authorPerry, Sarah L.
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.date2023-09-23T17:55:36.000
dc.date.accessioned2024-04-26T08:56:43Z
dc.date.available2017-04-07T00:00:00Z
dc.date.issued2017-01-01
dc.description.abstractCapturing protein structural dynamics in real-time has tremendous potential in elucidating biological functions and providing information for structure-based drug design. While time-resolved structure determination has long been considered inaccessible for a vast majority of protein targets, serial methods for crystallography have remarkable potential in facilitating such analyses. Here, we review the impact of microfluidic technologies on protein crystal growth and X-ray diffraction analysis. In particular, we focus on applications of microfluidics for use in serial crystallography experiments for the time-resolved determination of protein structural dynamics.
dc.identifier.doihttps://doi.org/http://dx.doi.org/10.1063/1.4979640
dc.identifier.urihttps://hdl.handle.net/20.500.14394/6128
dc.relation.ispartofStructural Dynamics
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1839&context=che_faculty_pubs&unstamped=1
dc.rightsUMass Amherst Open Access Policy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.issue4
dc.source.statuspublished
dc.subjectproteins
dc.subjectfluidic devices
dc.subjectcrystal structure
dc.subjectcrystallization
dc.subjectx-ray diffraction
dc.subjectChemical Engineering
dc.titleMicrofluidics: From Crystallization to Serial Time-Resolved Crystallography
dc.typearticle
dc.typearticle
digcom.contributor.authorSui, Shuo
digcom.contributor.authorisAuthorOfPublication|email:perrys@engin.umass.edu|institution:University of Massachusetts Amherst|Perry, Sarah L.
digcom.date.embargo2017-04-07T00:00:00-07:00
digcom.identifierche_faculty_pubs/840
digcom.identifier.contextkey9992080
digcom.identifier.submissionpathche_faculty_pubs/840
dspace.entity.typePublication
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