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Bioinorganic Chemistry of Nickel

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dc.contributor.authorMaroney, Michael J.
dc.contributor.authorCiurli, Stefano
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentUniversity of Bologna
dc.date2023-09-24T07:20:47.000
dc.date.accessioned2024-04-26T09:01:20Z
dc.date.available2021-09-28T00:00:00Z
dc.date.issued2019-01-01
dc.description.abstractNote: In lieu of an abstract, this is an excerpt from the first page. Following the discovery of the first specific and essential role of nickel in biology in 1975 (the dinuclear active site of the enzyme urease) [1], nickel has become a major player in bioinorganic chemistry, particularly in microorganisms, having impacts on both environmental settings and human pathologies. At least nine classes of enzymes are now known to require nickel in their active sites, including catalysis of redox [(Ni,Fe) hydrogenases, carbon monoxide dehydrogenase, methyl coenzyme M reductase, acetyl coenzyme A synthase, superoxide dismutase] and nonredox (glyoxalase I, acireductone dioxygenase, lactate isomerase, urease) chemistries. In addition, the dark side of nickel has been illuminated in regard to its participation in microbial pathogenesis, cancer, and immune responses. Knowledge gleaned from the investigations of inorganic chemists into the coordination and redox chemistry of this element have boosted the understanding of these biological roles of nickel in each context. In this issue, eleven contributions, including four original research articles and seven critical reviews, will update the reader on the broad spectrum of the role of nickel in biology.
dc.identifier.doihttps://doi.org/10.3390/inorganics7110131
dc.identifier.urihttps://hdl.handle.net/20.500.14394/6649
dc.relation.ispartofInorganics
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=2742&context=chem_faculty_pubs&unstamped=1
dc.rightsUMass Amherst Open Access Policy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.issue11
dc.source.issueBioinorganic Chemistry of Nickel
dc.source.issue7
dc.source.statuspublished
dc.titleBioinorganic Chemistry of Nickel
dc.typearticle
dc.typearticle
digcom.contributor.authorisAuthorOfPublication|email:mmaroney@chem.umass.edu|institution:University of Massachusetts Amherst|Maroney, Michael J.
digcom.contributor.authorisAuthorOfPublication|email:stefano.ciurli@unibo.it|institution:University of Bologna|Ciurli, Stefano
digcom.date.embargo2021-09-28T00:00:00-07:00
digcom.identifierchem_faculty_pubs/1475
digcom.identifier.contextkey25175909
digcom.identifier.submissionpathchem_faculty_pubs/1475
dspace.entity.typePublication
relation.isAuthorOfPublicationad3b9bd0-abfb-44e5-a9e2-23ada6472e39
relation.isAuthorOfPublication.latestForDiscoveryad3b9bd0-abfb-44e5-a9e2-23ada6472e39
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