SEX SPECIFIC ELECTROPHYSIOLOGY OF AROMATASE NEURONS IN THE MEDIAL AMYGDALA

Correia, Marcelo Henrique

Publication:
SEX SPECIFIC ELECTROPHYSIOLOGY OF AROMATASE NEURONS IN THE MEDIAL AMYGDALA

dc.contributor.advisor	Joseph Bergan
dc.contributor.advisor	Geng-Lin Li
dc.contributor.advisor	Luke Remage-Healey
dc.contributor.author	Correia, Marcelo Henrique
dc.contributor.department	University of Massachusetts Amherst
dc.contributor.department	Neuroscience & Behavior
dc.date	2023-09-23T23:25:51.000
dc.date.accessioned	2024-04-26T18:27:31Z
dc.date.available	2024-04-26T18:27:31Z
dc.date.submitted	September
dc.date.submitted	2019
dc.description.abstract	The medial amygdala (MeA) is a central node in the interwoven circuits that regulate social behavior based on pheromones. Aromatase-expressing (arom+) neurons in the MeA are key for the establishment and maintenance of sex differences. Here, we characterized the intrinsic electrophysiological properties of arom+ neurons and non-aromatase (arom-) neurons in the MeA of male and female mice. Most electrophysiological properties were similar for arom+ neurons in the MeA between sexes, but the relative refractory period was twice as large in female mice. We also show that the firing pattern and firing frequency is markedly different between arom+ and arom- neurons. The activity of MeA neurons could be modulated by estradiol, which reduced activity in arom+ neurons in males. The differences between arom+ and arom- neurons were observed in both sexes suggesting that aromatase expression delineates a neural population in the MeA with similar and unique electrophysiological properties.
dc.description.degree	Master of Science (M.S.)
dc.identifier.doi	https://doi.org/10.7275/14350640
dc.identifier.orcid	https://orcid.org/0000-0002-2091-1122
dc.identifier.uri	https://hdl.handle.net/20.500.14394/33881
dc.relation.url	https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1839&context=masters_theses_2&unstamped=1
dc.source.status	published
dc.subject	aromatase; medial amygdala; estradiol; sex differences; electrophysiology
dc.subject	Behavioral Neurobiology
dc.subject	Molecular and Cellular Neuroscience
dc.title	SEX SPECIFIC ELECTROPHYSIOLOGY OF AROMATASE NEURONS IN THE MEDIAL AMYGDALA
dc.type	openaccess
dc.type	article
dc.type	thesis
digcom.contributor.author	isAuthorOfPublication\|email:marcelohcorreia@gmail.com\|institution:University of Massachusetts Amherst\|Correia, Marcelo Henrique
digcom.identifier	masters_theses_2/824
digcom.identifier.contextkey	14350640
digcom.identifier.submissionpath	masters_theses_2/824
dspace.entity.type	Publication