Publication:
A role for serotonin in the hypothalamic-pituitary-adrenal response to insulin stress.

Simple item page
dc.contributor.authorYehuda, Rachel
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentPsychology
dc.date2023-09-23T13:25:56.000
dc.date.accessioned2024-04-26T20:51:55Z
dc.date.available2024-04-26T20:51:55Z
dc.date.issued1983
dc.description.abstractControversy exists concerning the possible involvement of serotonin in the pituitary-adrenocortical response to stress. In the present research, a variety of physiological and pharmacological manipulations were used in male rats to study the role of this neurotransmitter in the adrenocortical response to insulin- induced hypoglycemia. First, the effect of insulin stress on hypothalamic 5-HT metabolism was examined, and an increased turnover was found as determined by an enhanced accumulation of 5-HT following monoamine oxidase inhibition. The corticos terone response to insulin was potentiated by prior administration of L-tryptophan, and blocked by pretreatment with valine, an amino acid that competes with tryptophan for transport across the blood-brain barrier. Treatment with the 5-HT receptor blocker methysergide, or serotonin depletion by intraventricular injection of 5 , 7-dihydroxy tryptamine significantly attenuated the insulin- induced rise in circulating corticosterone.
dc.description.degreeThesis (M.S.)
dc.identifier.doihttps://doi.org/10.7275/7ja0-hy89
dc.identifier.oclc32295554
dc.identifier.urihttps://hdl.handle.net/20.500.14394/45842
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=3420&context=theses&unstamped=1
dc.source.statuspublished
dc.subjectInsulin resistance
dc.subjectSerotonin
dc.subjectPituitary-adrenal function tests
dc.titleA role for serotonin in the hypothalamic-pituitary-adrenal response to insulin stress.
dc.typeopen
dc.typearticle
dc.typethesis
digcom.contributor.authorYehuda, Rachel
digcom.identifiertheses/2284
digcom.identifier.contextkey7675995
digcom.identifier.submissionpaththeses/2284
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
roleforserotonin00yehu.pdf
Size:
3.37 MB
Format:
Adobe Portable Document Format
Name: roleforserotonin00yehu.pdf
Size: 3.37 MB
Kind: Adobe PDF
Collections
Masters Theses