Publication:
Differential Microglial Activation Following Immune Challenge in Peripubertal and Adult Outbred Mice

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dc.contributor.advisorJeffrey D Blaustein
dc.contributor.authorPlaczek, David J
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentNeuroscience & Behavior
dc.date2024-03-28T20:26:08.000
dc.date.accessioned2024-04-26T18:17:13Z
dc.date.available2024-04-26T18:17:13Z
dc.date.submittedMay
dc.date.submitted2015
dc.description.abstractPubertal development is a time of growth and development in the brain, leading to high sensitivity during this period. Past research in our lab has shown that shipping female inbred and outbred mice during pubertal development alters their sensitivity to steroid hormones in adulthood, thus affecting sexual receptivity, cognition, depression-like behavior, and anxiety-like behavior. Here, we test the hypothesis that mice treated with lipopolysaccharide during pubertal development would have more active microglia, the brain's immune cells, after injection than mice treated with lipopolysaccharide in adulthood. No significant interactions were observed between treatment and age between any brain area measured, suggesting that pubertal development does not render the brain's immune system hypersensitive to environmental stressors.
dc.description.degreeMaster of Science (M.S.)
dc.identifier.doihttps://doi.org/10.7275/7079420
dc.identifier.orcidN/A
dc.identifier.urihttps://hdl.handle.net/20.500.14394/33248
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1257&context=masters_theses_2&unstamped=1
dc.source.statuspublished
dc.subjectNeuroendocrinology
dc.subjectMice
dc.subjectStress
dc.subjectPuberty
dc.subjectSensitive
dc.subjectBrain
dc.subjectAnimals
dc.subjectBiological Phenomena, Cell Phenomena, and Immunity
dc.subjectOther Psychiatry and Psychology
dc.titleDifferential Microglial Activation Following Immune Challenge in Peripubertal and Adult Outbred Mice
dc.typeopenaccess
dc.typearticle
dc.typethesis
digcom.contributor.authorisAuthorOfPublication|email:dplaczek@cns.umass.edu|institution:University of Massachusetts Amherst|Placzek, David J
digcom.identifiermasters_theses_2/254
digcom.identifier.contextkey7079420
digcom.identifier.submissionpathmasters_theses_2/254
dspace.entity.typePublication
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