Publication:
Norbornene Based Polybetaines: Synthesis And Biological Applications

Simple item page
dc.contributor.advisorGregory N. Tew
dc.contributor.advisorDavid A. Hoagland
dc.contributor.advisorDhandapani Venkataraman
dc.contributor.authorColak, Semra
dc.contributor.departmentUniversity of Massachusetts - Amherst
dc.date2023-09-23T09:21:07.000
dc.date.accessioned2024-04-26T14:12:47Z
dc.date.available2014-06-13T00:00:00Z
dc.date.issued2012-02-01
dc.description.abstractPolymeric betaines gain considerable attention for their interesting solution properties, but even more so, for their favorable bio- and haemocompatible properties. When incorporated into materials or used as surface coatings, some of these zwitterionic polymers strongly resist protein absorption due to their hygroscopic nature, making betaines promising candidates for medical diagnostics, drug delivery, and tissue engineering applications. This dissertation introduces novel norbornene-based polybetaines as foundational materials for biological applications, including non-fouling coatings and antimicrobial macromolecules. Sulfo- and carboxybetaines, composed of backbones that do not contain hydrolyzable units under physiological conditions, as well as new polymers that carry a dual functionality at the repeat unit level, coupling a zwitterionic functionality with an alkyl moiety varied to adjust the amphiphilicity of the overall system, are introduced. How structural changes, backbone chemistry, hydrophilicity/amphiphilicity, and coating surface roughness impact their non-fouling properties is investigated.
dc.description.degreeDoctor of Philosophy (PhD)
dc.description.departmentPolymer Science and Engineering
dc.identifier.doihttps://doi.org/10.7275/5686583
dc.identifier.urihttps://hdl.handle.net/20.500.14394/13488
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1325&context=dissertations_1&unstamped=1
dc.source.statuspublished
dc.subjectApplied sciences
dc.subjectPure sciences
dc.subjectPolymeric betaines
dc.subjectNon-fouling coatings
dc.subjectNorbornene
dc.subjectAntimicrobial macromolecules
dc.subjectMaterials Science and Engineering
dc.subjectPolymer Chemistry
dc.titleNorbornene Based Polybetaines: Synthesis And Biological Applications
dc.typecampus
dc.typearticle
dc.typedissertation
digcom.contributor.authorColak, Semra
digcom.date.embargo2014-06-13T00:00:00-07:00
digcom.identifierdissertations_1/328
digcom.identifier.contextkey5686583
digcom.identifier.submissionpathdissertations_1/328
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Colak_umass_0118D_10941.pdf
Size:
3.17 MB
Format:
Adobe Portable Document Format
Name: Colak_umass_0118D_10941.pdf
Size: 3.17 MB
Kind: Adobe PDF
Collections
Dissertations