Publication:
NOVEL MASS SPECTROMETRY BASED STRATEGIES TO STUDY HEPARIN-PROTEIN INTERACTIONS

Simple item page
dc.contributor.advisorIgor A. Kaltashov
dc.contributor.authorNiu, Chendi
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.date2024-03-27T19:06:46.000
dc.date.accessioned2024-04-26T15:42:41Z
dc.date.available2024-04-26T15:42:41Z
dc.date.issued2020-09-01
dc.date.submittedSeptember
dc.date.submitted2020
dc.description.abstractHeparin and heparan sulfate (HS) are linear polyanions from the glycosaminoglycan (GAG) family. They are conceived to play critical roles in a variety of biophysiological processes by interacting with key proteins and regulating protein functions. Understanding their biological functions and exploit heparin’s unique versatility for therapeutic purposes critically depend on the characterization of their interactions with relevant proteins, which, however, is largely impeded by the structural heterogeneity of these polyanions. This work presented the development of novel mass spectrometry-based analytical strategies incorporated with liquid chromatography and ion mobility spectroscopy to investigate heparin-protein interactions and address their significance from different aspects.
dc.description.degreeDoctor of Philosophy (PhD)
dc.description.departmentChemistry
dc.identifier.doihttps://doi.org/10.7275/18801450
dc.identifier.orcidhttps://orcid.org/0000-0001-6662-819X
dc.identifier.urihttps://hdl.handle.net/20.500.14394/18355
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=3081&context=dissertations_2&unstamped=1
dc.source.statuspublished
dc.subjectAnalytical Chemistry
dc.subjectBiochemistry
dc.titleNOVEL MASS SPECTROMETRY BASED STRATEGIES TO STUDY HEPARIN-PROTEIN INTERACTIONS
dc.typecampusfive
dc.typearticle
dc.typedissertation
digcom.contributor.authorisAuthorOfPublication|email:chendiniu1118@hotmail.com|institution:University of Massachusetts Amherst|Niu, Chendi
digcom.identifierdissertations_2/2067
digcom.identifier.contextkey18801450
digcom.identifier.submissionpathdissertations_2/2067
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Dissertation_Niu_10202020.pdf
Size:
16.88 MB
Format:
Adobe Portable Document Format
Name: Dissertation_Niu_10202020.pdf
Size: 16.88 MB
Kind: Adobe PDF
Collections
Dissertations