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A Mathematical Model of Breast Tumor Progression Based on Immune Infiltration

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dc.contributor.authorMirzaei, Navi Mohammad
dc.contributor.authorSu, Sumeyye
dc.contributor.authorSofia, Dilruba
dc.contributor.authorHegarty, Maura
dc.contributor.authorAbel-Rahman, Mohamed H.
dc.contributor.authorAsadpoure, Alireza
dc.contributor.authorCebulla, Colleen M.
dc.contributor.authorChang, Young Hwan
dc.contributor.authorHao, Wenrui
dc.contributor.authorJackson, Pamela R.
dc.contributor.authorLee, Adrian V.
dc.contributor.authorStover, Daniel G.
dc.contributor.authorTatarova, Zuzana
dc.contributor.authorZervantonakis, Ioannis K.
dc.contributor.authorShahriyari, Leili
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.contributor.departmentOhio State University Comprehensive Cancer Center
dc.contributor.departmentUniversity of Massachusetts Dartmouth
dc.contributor.departmentOhio State University Comprehensive Cancer Center
dc.contributor.departmentOregon Health and Science University
dc.contributor.departmentThe Pennsylvania State University
dc.contributor.departmentMayo Clinic Arizona
dc.contributor.departmentUniversity of Pittsburgh
dc.contributor.departmentOhio State University Comprehensive Cancer Center
dc.contributor.departmentOregon Health and Science University
dc.contributor.departmentUniversity of Pittsburgh
dc.contributor.departmentUniversity of Massachusetts Amherst
dc.date2023-09-24T07:33:26.000
dc.date.accessioned2024-04-26T18:39:45Z
dc.date.available2021-11-19T00:00:00Z
dc.date.issued2021-01-01
dc.description.abstractBreast cancer is the most prominent type of cancer among women. Understanding the microenvironment of breast cancer and the interactions between cells and cytokines will lead to better treatment approaches for patients. In this study, we developed a data-driven mathematical model to investigate the dynamics of key cells and cytokines involved in breast cancer development. We used gene expression profiles of tumors to estimate the relative abundance of each immune cell and group patients based on their immune patterns. Dynamical results show the complex interplay between cells and molecules, and sensitivity analysis emphasizes the direct effects of macrophages and adipocytes on cancer cell growth. In addition, we observed the dual effect of IFN-γ" role="presentation" style="box-sizing: border-box; max-height: none; display: inline; line-height: normal; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; position: relative;">γ on cancer proliferation, either through direct inhibition of cancer cells or by increasing the cytotoxicity of CD8+ T-cells.
dc.identifier.doihttps://doi.org/10.3390/jpm11101031
dc.identifier.urihttps://hdl.handle.net/20.500.14394/34375
dc.relation.ispartofJournal of Personalized Medicine
dc.relation.urlhttps://scholarworks.umass.edu/cgi/viewcontent.cgi?article=2316&context=math_faculty_pubs&unstamped=1
dc.rightsUMass Amherst Open Access Policy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.issue10
dc.source.issue11
dc.source.statuspublished
dc.subjectbreast cancer
dc.subjectimmune infiltration
dc.subjectordinary differential equations
dc.subjectdata driven mathematical model
dc.subjectsensitivity analysis
dc.subjectadipocytes
dc.subjectestrogen
dc.subjectHMGB1
dc.subjectcytokines
dc.subjectT-cells
dc.subjectmacrophages
dc.subjectIFN-y
dc.titleA Mathematical Model of Breast Tumor Progression Based on Immune Infiltration
dc.typearticle
dc.typearticle
digcom.contributor.authorMirzaei, Navi Mohammad
digcom.contributor.authorSu, Sumeyye
digcom.contributor.authorSofia, Dilruba
digcom.contributor.authorHegarty, Maura
digcom.contributor.authorAbel-Rahman, Mohamed H.
digcom.contributor.authorAsadpoure, Alireza
digcom.contributor.authorCebulla, Colleen M.
digcom.contributor.authorChang, Young Hwan
digcom.contributor.authorHao, Wenrui
digcom.contributor.authorJackson, Pamela R.
digcom.contributor.authorLee, Adrian V.
digcom.contributor.authorStover, Daniel G.
digcom.contributor.authorTatarova, Zuzana
digcom.contributor.authorZervantonakis, Ioannis K.
digcom.contributor.authorShahriyari, Leili
digcom.date.embargo2021-11-19T00:00:00-08:00
digcom.identifiermath_faculty_pubs/1317
digcom.identifier.contextkey25986264
digcom.identifier.submissionpathmath_faculty_pubs/1317
dspace.entity.typePublication
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