This paper explores the conditions for DMO board effectiveness in destination management organizations (DMOs). First, three different measures for board effectiveness are identified: (1) good teamwork, (2) capability of realizing projects and initiatives, and (3) board strengthens the DMOs position in the destination. Second, a series of conditions as independent variables were selectively built from extant literature: (1) board size, (2) arguments, (3) dealing with crises, (4) mutual respect, (5) constructive discussions, and (6) taking the job seriously. Multiple regression results from 61 board members of 36 Swiss DMOs revealed that different conditions affect board effectiveness, depending on how the latter is identified. The paper concludes with indications for further research.